Somatic SNV/Indel caller benchmarking using virtual tumors

Background Evaluating somatic variant callers remains challenging due to lack of good reference datasets. With that in mind, we have recently sequenced and analyzed high coverage whole genome data from tumor cell lines along with their matched normal cell lines (Arora et al., 2019). Another good strategy for benchmarking somatic single nucleotide variants (SNVs) and […]

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