Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.
PMID: 36671517 PMCID: PMC9855758 DOI: 10.3390/biom13010133
Biomolecules. 2023 Jan 9;13(1):133. doi: 10.3390/biom13010133.
Nikhil Shri Sahajpal 1 2, Alex R Hastie 3, Maximilian Schieck 4 5, Ashis K Mondal 1, Marc Felde 6, Caspar I van der Made 7 8 9, Janet S Chou 10, Adrienne G Randolph 11 12, Thomas Illig 4 5, Michael C Zody 13, Catherine A Brownstein 14, Alan H Beggs 14, Alexander Hoischen 7 8 9, Alka Chaubey 3, Ravindra Kolhe 1; COVID19hostgenomesv Consortium
1Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
2Greenwood Genetic Center, Greenwood, SC 29646, USA.
3Bionano Genomics, Inc., San Diego, CA 92121, USA.
4Hannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany.
5RESIST-Cluster of Excellence 2155, Hannover Medical School, 30625 Hannover, Germany.
6Department of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.
7Department of Human Genetics, Radboud University Medical Center for Infectious Diseases (RCI), 6525 Nijmegen, The Netherlands.
8Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
9Radboud Expertise Center for Immunodeficiency and Autoinflammation, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
10Division of Immunology, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
11Department of Anesthesiology, Critical Care, and Pain Medicine, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
12Departments of Anesthesia and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
13New York Genome Center, New York, NY 10013, USA.
14Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
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