Publications

Adult Human Glioblastomas Harbor Radial Glia-like Cells

Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner. Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal radial glia and that reside in quiescent and cycling states. Functional assays show a role for interleukin in triggering exit from dormancy into active cycling, suggesting a role for inflammation in tumor progression. These data are consistent with the possibility of persistence of RG into adulthood and their involvement in tumor initiation or maintenance. They also provide a putative cellular basis for the persistence of normal developmental programs in adult tumors.

Stem Cell Reports. 2020 Feb 11;14(2):338-350. doi: 10.1016/j.stemcr.2020.01.007.

Other Contributors

Rong Wang 1, Roshan Sharma 2, Xiaojuan Shen 3, Ashley M Laughney 4, Kosuke Funato 1, Philip J Clark 5, Monika Shpokayte 6, Peter Morgenstern 1, Monalisa Navare 1, Yichi Xu 7, Shaghayegh Harbi 8, Ignas Masilionis 9, Gouri Nanjangud 10, Yanhong Yang 1, Gabriel Duran-Rehbein 1, Martin Hemberg 11, Dana Pe’er 9, Viviane Tabar 12
Affiliations 

Affiliations

  • 1Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • 2Program for Computational and Systems Biology, Sloan Kettering Institute, New York, NY 10065, USA; New York Genome Center, New York, NY 10013, USA.
  • 3Wellcome Sanger Institute, Hinxton, Cambridgshire CB10 1SA, UK; ShaoYang University, Shaoyang, Hunan, China.
  • 4Cancer Biology and Genetics Program, Sloan Kettering Institute, New York, NY 10065, USA.
  • 5Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Neurobiology and Anatomy, Drexel University College of Medicine, PA 64742, USA.
  • 6Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Brain Science, Harvard University, Boston, MA 02138, USA.
  • 7Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA.
  • 8VasculoTox, Inc. New York, NY 10010, USA.
  • 9Program for Computational and Systems Biology, Sloan Kettering Institute, New York, NY 10065, USA.
  • 10Molecular Cytology Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • 11Wellcome Sanger Institute, Hinxton, Cambridgshire CB10 1SA, UK.
  • 12Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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